Kallianpur, Kalpana PhD

Scientific Highlights

2012-2013 Pilot Project Award

Cerebrovascular Risk Factors and Altered Brain Structure in Healthy Individuals

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Description
Cerebrovascular disease (CVD) is the third leading cause of death in both Hawai’i and the entire U.S. Diabetes, dyslipidemia, hypertension and other cardiometabolic disorders, which are over-represented in the Native Hawaiian population, are risk factors not only for myocardial infarction and stroke but for vascular dementia and mixed vascular dementia/Alzheimer’s Disease. Utilizing Hawaii-wide hospital discharge records, we recently identified a substantial health disparity in dementia prevalence, and in particular of vascular dementia, among Native Hawaiians. Determining the relationships between cognitive dysfunction and specific cerebrocardiovascular risk factors such as hypertension, cholesterol, and diabetes will prove crucial to the planning of preventive and treatment strategies and ultimately to understanding the mechanism that underlies CVD-related dementias. Vascular neurocognitive impairment in CVD reflects damage to global gray and white matter, especially in the deep gray nuclei and frontal cortex. This RMA TRIX project proposes to examine structural brain changes cross-sectionally in 50 ‘healthy’ middle-aged and elderly adults (age ≥ 40 years) who have varying degrees of CVD risk factors. Specifically, we will use magnetic resonance imaging (MRI) to assess alterations in regional cortical thickness, a sensitive measure of macrostructural gray matter change. We will also employ a newer neuroimaging modality, diffusion tensor imaging (DTI), to examine microstructural abnormalities in white matter and subcortical gray matter regions. Associations between individual cerebrovascular risk factors and regional brain tissue integrity, both macrostructural and microstructural, will be investigated with these two
techniques.

Health Initiative
Nutrition & Metabolic; Cardiovascular; Aging & Neurocognitive

Collaboration & Partnerships
Leahi Hospital, Oahu, HI

Progress
METHODS: Using MRI and Diffusion Tensor Imaging participants will be evaluated for CVD risk factors. Magnetic resonance imaging (MRI) will be used to assess alterations in regional cortical thickness, a sensitive measure of macrostructural gray matter change; and using a newer neuroimaging modality, diffusion tensor imaging (DTI), microstructural abnormalities in white matter and subcortical gray matter regions will be examined.

CONCLUSIONS: Data are currently being analyzed that suggest CVD risk factors may have unique characteristics in the brain.

Selected Publications

• Chow D, Nakamoto BK, Sullivan K, Sletten DM, Fujii S, Umekawa S, Kocher M, Kallianpur KJ, Shikuma CM, Low P.
  Symptoms of Autonomic Dysfunction in Human Immunodeficiency Virus.
  Open Forum Infect Dis 2015 [more...]


• Munger AM, Chow DC, Playford MP, Parikh NI, Gangcuangco LM, Nakamoto BK, Kallianpur KJ, Ndhlovu LC, Shikuma CM, Mehta NN.
  Characterization of lipid composition and high-density lipoprotein function in HIV-infected individuals on stable antiretroviral regimens.
  AIDS Res Hum Retroviruses 2015 [more...]


• Kallianpur KJ, Valcour VG, Lerdlum S, Busovaca E, Agsalda M, Sithinamsuwan P, Chalermchai T, Fletcher JL, Tipsuk S, Shikuma CM, Shiramizu BT, Ananworanich J, Wendelken L, Desai A, Hutchings N, Chomchey N, Jirajariyavej S, Chaisit P, Chinvarun Y, Thongkramjaroen P, Thongmuang S, Jarupittaya S, Khongtia P, Jadwattanakul T, Methajittiphun P, Mingkwanrungruang P, Chalermchai T, Phanuphak N, Kroon E, Terratakulpisarn N, Suttichom D, Rattanamanee S, Boonchan M.
  HIV DNA in CD14+ reservoirs is associated with regional brain atrophy in patients naive to combination antiretroviral therapy.
  AIDS 2014 [more...]


• Ndhlovu LC, Umaki T, Chew GM, Chow DC, Agsalda M, Kallianpur KJ, Paul R, Zhang G, Ho E, Hanks N, Nakamoto B, Shiramizu BT, Shikuma CM.
  Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for...
  J Neurovirol 2014 [more...]


• Shikuma CM, Chow DC, Gangcuangco LM, Zhang G, Keating SM, Norris PJ, Seto TB, Parikh N, Kallianpur KJ, Nakamoto BK, Nagamine LS, Ndhlovu LC, Barbour JD.
  Monocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV.
  PLoS One 2014 [more...]


• Chow D, Nakamoto B, So E, Parikh N, Souza S, Kallianpur K, Shikuma C.
  Rates of autonomic dysfunction in HIV patients receiving antiretroviral therapy.
  J Neurovirol 2013 [more...]


• Gangcuangco LM, Chow DC, Liang CY, Nakamoto BK, Umaki TM, Kallianpur KJ, Shikuma CM.
  Predictors of 25-hydroxyvitamin D levels in HIV-infected patients in Hawai'i.
  Hawaii J Med Public Health 2013 [more...]


• Kallianpur KJ, Shikuma C, Kirk GR, Shiramizu B, Valcour V, Chow D, Souza S, Nakamoto B, Sailasuta N.
  Peripheral blood HIV DNA is associated with atrophy of cerebellar and subcortical gray matter.
  Neurology 2013 [more...]


• Lin C, Grandinetti A, Shikuma C, Souza S, Parikh N, Nakamoto B, Kallianpur KJ, Chow D.
  The effects of extended release niacin on lipoprotein sub-particle concentrations in HIV-infected patients.
  Hawaii J Med Public Health 2013 [more...]


• Nakamoto BK, Shikuma CM, Ogata-Arakaki D, Umaki T, Neuwelt EA, Shiramizu BT, Chow DC, Parikh NI, Kallianpur KJ, Hamilton BE.
  Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder.
  J Neurovirol 2013 [more...]


• Tongma C, Shikuma CM, Nakamoto BK, Kallianpur KJ, Umaki TM, Barbour JD, Ndhlovu L, Parikh NI, Chow DC.
  Albuminuria as a marker of cardiovascular risk in HIV-infected individuals receiving stable antiretroviral therapy.
  Hawaii J Med Public Health 2013 [more...]


• Umaki TM, Gangcuangco LM, Chow DC, Nakamoto BK, Marotz L, Kallianpur KJ, Shikuma CM.
  Poorer neuropsychological performance increases risk for social services among HIV-infected individuals.
  Hawaii J Med Public Health 2013 [more...]


• Derauf C, Lester BM, Neyzi N, Kekatpure M, Gracia L, Davis J, Kallianpur K, Efird JT, Kosofsky B.
  Subcortical and cortical structural central nervous system changes and attention processing deficits in preschool-aged children with prenatal methamphetamine and tobacco exposure.
  Dev Neurosci 2012 [more...]


• Kallianpur KJ, Kirk GR, Sailasuta N, Valcour V, Shiramizu B, Nakamoto BK, Shikuma C.
  Regional cortical thinning associated with detectable levels of HIV DNA.
  Cereb Cortex 2012 [more...]


• Nakamoto BK, Jahanshad N, McMurtray A, Kallianpur KJ, Chow DC, Valcour VG, Paul RH, Marotz L, Thompson PM, Shikuma CM.
  Cerebrovascular risk factors and brain microstructural abnormalities on diffusion tensor images in HIV-infected individuals.
  J Neurovirol 2012 [more...]


• Shikuma CM, Nakamoto B, Shiramizu B, Liang CY, DeGruttola V, Bennett K, Paul R, Kallianpur K, Chow D, Gavegnano C, Hurwitz SJ, Schinazi RF, Valcour VG.
  Antiretroviral monocyte efficacy score linked to cognitive impairment in HIV.
  Antivir Ther 2012 [more...]


• Nakamoto BK, Valcour VG, Kallianpur K, Liang CY, McMurtray A, Chow D, Kappenburg E, Shikuma CM.
  Impact of cerebrovascular disease on cognitive function in HIV-infected patients.
  J Acquir Immune Defic Syndr 2011 [more...]


• Shimizu SM, Chow DC, Valcour V, Masaki K, Nakamoto B, Kallianpur KJ, Shikuma C.
  The Impact of Depressive Symptoms on Neuropsychological Performance Tests in HIV-Infected Individuals: A Study of the Hawaii Aging with HIV Cohort.
  World J AIDS 2011 [more...]


• Nakamoto BK, McMurtray A, Davis J, Valcour V, Watters MR, Shiramizu B, Chow DC, Kallianpur K, Shikuma CM.
  Incident neuropathy in HIV-infected patients on HAART.
  AIDS Res Hum Retroviruses 2010 [more...]