Publication Detail

Citation : Horton JS, Buckley CL, Stokes AJ. (2013)
Successful TRPV1 antagonist treatment for cardiac hypertrophy and heart failure in mice.
Channels (Austin) 7(1):17-22.
Abstract : Heart failure is becoming a global epidemic. It exerts a staggering toll on quality of life, and substantial medical and economic impact. In a pre-clinical model of cardiac hypertrophy and heart failure, we were able to overcome loss of heart function by administering the TRPV1 antagonist BCTC (4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide). The results presented here identify TRPV1 antagonists as new treatment options for cardiac hypertrophy and heart failure.
URL Link :
PMID : 23221478
PMCID : PMC3589277
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