Publication Detail

Citation : Kallianpur KJ, Valcour VG, Lerdlum S, Busovaca E, Agsalda M, Sithinamsuwan P, Chalermchai T, Fletcher JL, Tipsuk S, Shikuma CM, Shiramizu BT, Ananworanich J, Wendelken L, Desai A, Hutchings N, Chomchey N, Jirajariyavej S, Chaisit P, Chinvarun Y, Thongkramjaroen P, Thongmuang S, Jarupittaya S, Khongtia P, Jadwattanakul T, Methajittiphun P, Mingkwanrungruang P, Chalermchai T, Phanuphak N, Kroon E, Terratakulpisarn N, Suttichom D, Rattanamanee S, Boonchan M. (2014)
HIV DNA in CD14+ reservoirs is associated with regional brain atrophy in patients naive to combination antiretroviral therapy.
AIDS 28(11):1619-24.
Abstract : HIV DNA burden in CD14 monocytes is directly linked to brain volumetric loss. Our findings implicate peripheral viral reservoirs in HIV-associated brain atrophy and support their involvement in the neuropathogenesis of HAND, underscoring the need for therapies that target these cells.
URL Link :
PMID : 25232899
PMCID : PMC4170526
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