Publication Detail

Citation : Nakamoto BK, Shikuma CM, Ogata-Arakaki D, Umaki T, Neuwelt EA, Shiramizu BT, Chow DC, Parikh NI, Kallianpur KJ, Hamilton BE. (2013)
Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder.
J Neurovirol 19(6):601-5.
Abstract : We assessed ferumoxytol-enhanced brain MRI to identify monocyte/macrophage accumulation in HIV-associated neurocognitive disorder (HAND). Four HIV-infected subjects with undetectable HIV RNA levels on antiretroviral therapy, HIV DNA level in CD14+ cells â?¥10 copies/10(6) cells, and cognitive impairment underwent ferumoxytol-enhanced brain MRI. On post-ferumoxytol susceptibility-weighted images, all HIV-infected subjects demonstrated a diffuse "tram track" appearance in the perivascular regions of cortical and deep white matter vessels suggesting ferumoxytol uptake in monocytes/macrophages. This finding was not present in an HIV-seronegative control. While ferumoxytol may have potential as an imaging biomarker for monocyte/macrophage accumulation in patients with HAND, future study is needed.
URL Link : http://www.ncbi.nlm.nih.gov/pubmed/24129909
PMID : 24129909
PMCID : PMC3947641
News
02 February 2018:
The Mary Kay Foundation - GRANT APPLICATION ANNOUNCEMENT

The Mary Kay Foundation

GRANT APPLICATION ANNOUNCEMENT

Applications are accepted from
November 2, 2017 through February 2, 2018

DEADLINE is …

08 December 2017:
F31 Award Submission Alert

The Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (F31 …

06 November 2017:
NRMN Grant Writing Coaching Group Applications

Are you preparing a proposal to submit to NIH in the upcoming months? Do you want to be coached on effective writing techniques from experienced grant…


View more news...


Seminars & Events
16 June 2017, 9am - 10:30am:
HEALTH & MEDICINE SEMINAR - Kukulu Ola Hou
02 June 2017, 8:15am - 4:10pm:
PROMOTING EXCELLENCE IN CLINICAL RESEARCH
02 November 2016, 9am:
RMATRIX-II Collaboration Pilot Projects Program 2017 -- Informational Webinar

View more seminars & events...

Supported by a grant from the National Institute on Minority Health and Health Disparities (U54MD007584), National Institutes of Health.