Seminar/Event Detail

HIV Vaccine Design by Directed Evolution of Glycostructures

Date/Time: 15 December 2015, 12noon - 1pm
Speaker: Isaac Krauss, PhD
Speaker Affiliation: Brandeis University
Venue: JABSOM, MEB 301
For more info: Iain MacPherson (692-1643)

Description: More Information On Dr. Krauss’ Work:

Our chemical biology program is directed at the design and synthesis of carbohydrate clusters which mimic important binding surfaces in biology. One target is the portion of HIV protein gp120 which is bound by 2G12, a broadly-neutralizing antibody which protects against the virus. Good mimics of this glycocluster have potential as HIV vaccines. Rather than design and test individual glycoclusters, we are using a directed evolution-based approach, in which the best gp120 mimics are selected from a diverse glycocluster library by their ability to bind 2G12. This directed evolution is accomplished by attachment of sugars to a library of DNA sequences using click chemistry, a technique which we term SELMA (SELection with Modified Aptamers). We are also applying SELMA and related methods to other problems in molecular recognition.

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Supported by a grant from the National Institute on Minority Health and Health Disparities (U54MD007584), National Institutes of Health.