Seminar/Event Detail

Statistical Issues in Evaluating the Efficacy of Personalized Medicine

Date/Time: 05 November 2012, 2pm - 3pm
Speaker: Dr. Motomi Mori
Speaker Affiliation: Oregon Health & Science University
Venue: JABSOM MEB Rm. 304
For more info: JABSOM BDMC at 692.1814.

Description: With the advance of high-throughput genetics/genomics technology, the concept of personalized medicine is becoming a realistic possibility. In this presentation, we will discuss statistical issues involved in evaluation of the clinical utility of “personalized medicine” using an example of a novel in-vitro screening assay developed by cancer researchers at OHSU. The in-vitro kinase inhibitor assays evaluate sensitivity of primary leukemia cells against a panel of small-molecule kinase inhibitors. It is hypothesized that the assay results can help identify molecularly targeted drugs to which a patient is most likely to respond. Several phase II trial designs were proposed and their operating characteristics were evaluated through simulation. We will present the results of the simulation study and discuss general statistical issues/challenges involved in testing a personalized medicine strategy. These include trial design, patient eligibility, selection of endpoints and control group, randomization, sample size and analysis strategies.

The event is kindly supported by RCMI Multidisciplinary and Translational Research Infrastructure Expansion in Hawaii (RMATRIX: U54MD007584), Bioscience Research Infrastructure Development for Grant Enhancement and Success (BRIDGES: G12MD007602), and IDeA Networks of Biomedical Research Excellence (INBRE: P20GM103466).

Additional Document:Click here to download

News
02 February 2018:
The Mary Kay Foundation - GRANT APPLICATION ANNOUNCEMENT

The Mary Kay Foundation

GRANT APPLICATION ANNOUNCEMENT

Applications are accepted from
November 2, 2017 through February 2, 2018

DEADLINE is …

08 December 2017:
F31 Award Submission Alert

The Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (F31 …

06 November 2017:
NRMN Grant Writing Coaching Group Applications

Are you preparing a proposal to submit to NIH in the upcoming months? Do you want to be coached on effective writing techniques from experienced grant…


View more news...


Seminars & Events
16 June 2017, 9am - 10:30am:
HEALTH & MEDICINE SEMINAR - Kukulu Ola Hou
02 June 2017, 8:15am - 4:10pm:
PROMOTING EXCELLENCE IN CLINICAL RESEARCH
02 November 2016, 9am:
RMATRIX-II Collaboration Pilot Projects Program 2017 -- Informational Webinar

View more seminars & events...

Supported by a grant from the National Institute on Minority Health and Health Disparities (U54MD007584), National Institutes of Health.