Publication Detail

Citation : Horton JS, Stokes AJ. (2014)
The transmembrane channel-like protein family and human papillomaviruses: Insights into epidermodysplasia verruciformis and progression to squamous cell carcinoma.
Oncoimmunology 3(1):e28288.
Abstract : Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by increased sensitivity to infection by the �²-subtype of human papillomaviruses (�²-HPVs), causing persistent, tinea versicolor-like dermal lesions. In a majority of affected individuals, these macular lesions progress to invasive cutaneous squamous cell carcinoma (CSCC) in sun-exposed areas. While mutations in transmembrane channel-like 6 (TMC6 / EVER1) and 8 (TMC8 / EVER2) have been causally linked to EV, their molecular functions are unclear. It is likely that their protective effects involve regulation of the �²-HPV life cycle, host keratinocyte apoptosis vs. survival balance and/or T-cell interaction with infected host cells.
URL Link : http://www.ncbi.nlm.nih.gov/pubmed/24800179
PMID : 24800179
PMCID : PMC4006860
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