Publication Detail

Citation : Shikuma CM, Gangcuangco LM, Killebrew DA, Libutti DE, Chow DC, Nakamoto BK, Liang CY, Milne CI, Ndhlovu LC, Barbour JD, Shiramizu BT, Gerschenson M. (2014)
The role of HIV and monocytes/macrophages in adipose tissue biology.
J Acquir Immune Defic Syndr 65(2):151-9.
Abstract : Circulating HIV-infected and proinflammatory CD14CD16 monocyte subsets contribute to the pathogenesis of HIV-associated lipoatrophy. Among HIV-infected individuals, macrophages, rather than adipocytes, are the primary source of low-grade inflammation in subcutaneous adipose tissue. HIV infection modifies these macrophages to a more proinflammatory phenotype, and these changes are not substantially mitigated by the use of ART.
URL Link : http://www.ncbi.nlm.nih.gov/pubmed/24091690
PMID : 24091690
PMCID : PMC4020346
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