Publication Detail

Citation : Shikuma CM, Chow DC, Gangcuangco LM, Zhang G, Keating SM, Norris PJ, Seto TB, Parikh N, Kallianpur KJ, Nakamoto BK, Nagamine LS, Ndhlovu LC, Barbour JD. (2014)
Monocytes expand with immune dysregulation and is associated with insulin resistance in older individuals with chronic HIV.
PLoS One 9(2):e90330.
Abstract : MO levels increase with worsening HIV immune dysregulation as assessed by CD4 percent. CD4 percent may provide additional information about MO and metabolic risk in this population beyond absolute values. MO, and specifically classical MO, may contribute to insulin resistance and metabolic syndrome during chronic HIV infection. Multiple soluble plasma biomarkers including tPAI-1 increase with increase in MO. Levels of tPAI-1 independently predict the development of insulin resistance.
URL Link : http://www.ncbi.nlm.nih.gov/pubmed/24587328
PMID : 24587328
PMCID : PMC3937368
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