Publication Detail

Citation : Shimizu SM, Chow DC, Valcour V, Masaki K, Nakamoto B, Kallianpur KJ, Shikuma C. (2011)
The Impact of Depressive Symptoms on Neuropsychological Performance Tests in HIV-Infected Individuals: A Study of the Hawaii Aging with HIV Cohort.
World J AIDS 1(4):139-145.
Abstract : BACKGROUND: The frequency of neurocognitive impairment (NCI) in human immunodeficiency virus (HIV)-infected individuals remains high despite the availability of potent antiretroviral therapy (ART). The concurrence of depression among HIV-infected patients with NCI is common, especially among older individuals. Depression has been implicated as a risk factor for impaired neuropsychological performance (NP). This study explored the relationship between depressive symptoms and NP testing in HIV-infected individuals. METHODS: A cross-sectional analysis was performed within the Hawaii Aging with HIV Cohort, a large prospective study of cognition of older (50 or more years old) compared to younger (20 to 39 years old) HIV-infected individuals. RESULTS: Two hundred and eighty-five HIV infected participants (157 older and 128 younger) were administered a battery of NP tests to measure performance in major cognitive domains. Depressive symptoms were measured using the Beck Depression Inventory (BDI). The rates of depressive symptoms and neuropsychological impairment were similar in older and younger groups. Multivariate analyses revealed depressive symptoms were associated with NP test impairment in the younger group. In the older group, depressive symptoms were not associated with NP. CONCLUSION: This study suggests that depressive symptoms are associated with NP test impairment in younger HIV-infected individuals, but not in older individuals.
URL Link :
PMID : 23061029
PMCID : PMC3467015
15 September 2017:
RCMI Conference Travel Support

We are currently encouraging scientists engaged in health disparities research, healthcare and public health professionals, public policy professional…

10 September 2017:
Call for Abstracts: RCMI Translational Science 2017 Conference

Call for Abstracts

Abstract Deadline Extended

Submit Your Abstracts

Abstract submission for oral and poster presentations is…

16 May 2017:
Robert Wood Johnson Funding Opportunity

If our nation is to make the opportunity for health available to all, we need leaders who will be able to meet the challenges before us – leade…

View more news...

Seminars & Events
16 June 2017, 9am - 10:30am:
02 June 2017, 8:15am - 4:10pm:
02 November 2016, 9am:
RMATRIX-II Collaboration Pilot Projects Program 2017 -- Informational Webinar

View more seminars & events...

Supported by a grant from the National Institute on Minority Health and Health Disparities (U54MD007584), National Institutes of Health.