Publication Detail

Citation : Tse GG, Santos-Ocampo AS, Chow DC, McMurtray AM, Nakamoto BK. (2013)
Diffuse leukoencephalopathy and subacute parkinsonism as an early manifestation of systemic lupus erythematosus.
Case Rep Neurol Med 2013367185.
Abstract : Parkinsonism in SLE is rare. Diffuse leukoencephalopathy is equally uncommon and is associated with a poor prognosis. We present a single case of a 50-year-old Filipino man who presented with a generalized discoid rash after starting lisinopril. The rash persisted despite discontinuation of lisinopril, and over the next three months, he developed rapidly progressive parkinsonism. Brain MRI showed symmetric confluent T2-hyperintensities involving the white matter and basal ganglia. Four of the 11 American College of Rheumatology criteria for the classification of SLE were met. A rheumatologist made a diagnosis of SLE with cutaneous and central nervous system involvement. Significant neurologic and radiologic improvement occurred following treatment with IV steroids followed by a prolonged taper. This report highlights a case of subacute parkinsonism with a diffuse leukoencephalopathy as an early manifestation of SLE which resulted in a good recovery following treatment with only immunosuppressive therapy.
URL Link : http://www.ncbi.nlm.nih.gov/pubmed/24369514
PMID : 24369514
PMCID : PMC3863508
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