photo

Bandar, Ivo Sah MD, PhD

Pilot Project PI
Adjunct Instructor (Genetic Research Scientist)
Hawaii Center for AIDS & Department of Tropical Medicine Medical Microbiology & Pharmacology
John A. Burns School of Medicine
University of Hawai’i at Manoa

(808) 692-1665
ivosb@hawaii.edu




Research Overview

2014-2015 RMATRIX Collaboration Pilot Projects Program Awards

Project Description

Title: Monocyte Inflammation and Metabolic Disorders
Principal Investigator: Ivo Sah Bandar, MD, PhD
RMATRIX HEALTH Initiative(s): Nutrition & Metabolic
RMATRIX Core Support: Biostatistics & Health Sciences Data Analytics, Regulatory Knowledge and Support

Abstract

Metabolic disorder is one of the leading causes of major health problems worldwide. Diabetes has been a significant health burden in the State of Hawaii and also disproportionately impacting Native Hawaiian and Other Pacific Islanders (NHOPI), and Asian Americans. Insulin resistance is a condition underlying diabetes and pre-diabetes and is linked to chronic inflammation, including the process that involves monocytes. Monocytes are circulating cells with inflammatory properties and appear to play a crucial role in the pathogenesis of cardiometabolic disorders, including insulin resistance and diabetes, through mechanisms that are still unclear. Peripheral blood monocytes are currently classified into three subsets based on CD14 and CD16 expression. Our recent studies have uncovered a 4th as yet uncharacterized monocyte subset, which appear to be segregated from the other subsets and associated with atherosclerotic disease markers in our HIV-infected adult. We have also demonstrated that among HIV-infected individuals on stable antiretroviral therapy, (ART), there is an increase in classical monocytes linked to insulin resistance in older individuals with chronic HIV infection, but whether this is applicable to the HIV-uninfected population remains unknown. Based on these findings, we wish to understand the role of monocyte in insulin resistance within the general population in Hawaii. Our hypothesis is that, similar to our HIV-infected population, monocyte inflammation will be directly linked to insulin resistance in the general population. Specifically, in this study, we propose to characterize monocyte phenotype and function from viably preserved banked peripheral blood mononuclear cell (PBMC) available from 75 HIV-uninfected individuals who participated in the Hawaii Aging with HIV Cohort (HAHC) study.

News
01 October 2018:
Ola HAWAII Team-Science Pilot Projects Program 2019 Call for Abstracts

Ola HAWAII

Team-Science Pilot Projects Program

2019 Call for Abstracts

NIH/NIMHD U54MD007601

We are pleased to announce an opportunity for…

13 September 2018:
Advance to Funding (ATF) Mock Study Section

The Mountain West CTR-IN offers researchers with faculty appointments at our partner institutions the opportunity to have an NIH Study Section-like ex…

23 July 2018:
2018 Health Disparities Research Institute

Apply Now to the 2018 Health Disparities Research Institute!

The National Institute on Minority Health and Health Disparities (NIMHD) will host the…


View more news...


Seminars & Events
18 October 2018, 11:00am - 2:00pm:
Data Security & Privacy
06 September 2018, 11:30am - 1:00pm:
Ola HAWAII Forum - Brown Bag Session
18 April 2018, 8am:
ANNUAL BIOMEDICAL SCIENCES and HEALTH DISPARITIES SYMPOSIUM

View more seminars & events...

Supported by a grant from the National Institute on Minority Health and Health Disparities (U54MD007584), National Institutes of Health.