Publication Detail
Citation : |
Laczko R, Szauter KM, Csiszar K. (2014)
LOXL1-associated candidate epithelial pathomechanisms in exfoliation glaucoma.
J Glaucoma 23(8 Suppl 1):S43-7.
|
Abstract : |
Results of the present study support ocular epithelia-specific LOXL1 functions in exfoliation glaucoma that may include both dysregulated extracellular matrix cross-linking activity and cellular mechanisms involving a role for LOXL1, in direct interaction with Snail1, in promoting epithelial to mesenchymal transition and a potential shift towards fibrogenic epithelial cell phenotypes.
|
URL Link : |
http://www.ncbi.nlm.nih.gov/pubmed/25275905
|
PMID : |
25275905
|
PMCID : |
PMC4205763
|
|
|
Supported by a grant from the National Institute on Minority Health and Health Disparities (U54MD007584), National Institutes of Health.